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General Information
DRAVP ID DRAVPe01564
Peptide Name Apelin-12
Sequence RPRLSHKGPMPF
Sequence Length 12
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Reverse transcriptase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target APJ receptor
Mechanism APJ receptor could help HIV virus enter the target cells. The peptide can bind with APJ receptor and block virus entry, thus inhibiting virus infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01564
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C64H103N21O14S
Absent amino acids ACDEINQTVWY
Common amino acids P
Mass 1422.71
Pl 12.01
Basic residues 4
Acidic residues 0
Hydrophobic residues 2
Net charge 4
Boman Index -3226
Hydrophobicity -113.33
Aliphatic Index 32.5
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Apelin peptides block the entry of human immunodeficiency virus (HIV).
Pubmed ID 10802050
Reference FEBS Lett. 2000 May 4;473(1):15-8.
Author Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.