To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01565
Peptide Name Apelin-13
Sequence QRPRLSHKGPMPF
Sequence Length 13
UniProt ID Q9TUI9 A0A484GMR2 A0A5N3XG03 A0A2Y9M6A9 A0A5G2R3Z5 A0A2Y9SZ03 A0A2U4A1K6
Source Bos taurus (Bovine)
Activity Information
Target Organism HIV
Assay Reverse transcriptase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target APJ receptor
Mechanism APJ receptor could help HIV virus enter the target cells. The peptide can bind with APJ receptor and block virus entry, thus inhibiting virus infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01565
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C69H111N23O16S
Absent amino acids ACDEINTVWY
Common amino acids P
Mass 1550.84
Pl 12.01
Basic residues 4
Acidic residues 0
Hydrophobic residues 2
Net charge 4
Boman Index -3780
Hydrophobicity -131.54
Aliphatic Index 30
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Apelin peptides block the entry of human immunodeficiency virus (HIV).
Pubmed ID 10802050
Reference FEBS Lett. 2000 May 4;473(1):15-8.
Author Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.