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General Information
DRAVP ID DRAVPe01566
Peptide Name Apelin-17
Sequence KFRRQRPRLSHKGPMPF
Sequence Length 17
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Reverse transcriptase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target APJ receptor
Mechanism APJ receptor could help HIV virus enter the target cells. The peptide can bind with APJ receptor and block virus entry, thus inhibiting virus infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01566
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C96H156N34O20S
Absent amino acids ACDEINTVWY
Common amino acids R
Mass 2138.57
Pl 12.48
Basic residues 7
Acidic residues 0
Hydrophobic residues 3
Net charge 7
Boman Index -7021
Hydrophobicity -160
Aliphatic Index 22.94
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Apelin peptides block the entry of human immunodeficiency virus (HIV).
Pubmed ID 10802050
Reference FEBS Lett. 2000 May 4;473(1):15-8.
Author Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.