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General Information
DRAVP ID DRAVPe01570
Peptide Name Apelin-15-(63-75)-peptide
Sequence RRQRPRLSHKGPM
Sequence Length 13
UniProt ID Q9TUI9
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Reverse transcriptase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target APJ receptor
Mechanism APJ receptor could help HIV virus enter the target cells. The peptide can bind with APJ receptor and block virus entry, thus inhibiting virus infection.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01570
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C67H119N29O16S
Absent amino acids ACDEFINTVWY
Common amino acids R
Mass 1618.93
Pl 12.48
Basic residues 6
Acidic residues 0
Hydrophobic residues 1
Net charge 6
Boman Index -7062
Hydrophobicity -210
Aliphatic Index 30
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.
Pubmed ID 11090199
Reference J Virol. 2000 Dec;74(24):11972-6.
Author Cayabyab M, Hinuma S, Farzan M, Choe H, Fukusumi S, Kitada C, Nishizawa N, Hosoya M, Nishimura O, Messele T, Pollakis G, Goudsmit J, Fujino M, Sodroski J.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.