DRAVP ID  DRAVPe01578

Peptide Name   #4330 derived from HIV-1 integrase

Sequence  KGEAMHGQVDCSPGIWQLDC

Sequence Length  20

UniProt ID  P04587 

Source  Synthetic construct

Target Organism  HIV

Assay  Assay for the enzymatic activities of RT

Activity 

• [Ref.17257575]HIV-1:inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(IC50=4 μM);inhibition of reverse transcriptase(DNA-dependent DNA polymerase) activity(IC50=6.8 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Reverse Transcriptase

Mechanism  The peptide could bind the reverse transcriptase and inhibits its DNA-polymerase activity and thus inhibits virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe01578

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.

Pubmed ID   17257575

Reference   Arch Biochem Biophys. 2007 Feb 15;458(2):202-12.

Author   Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.

DOI   10.1016/j.abb.2006.12.007