DRAVP ID  DRAVPe01578

Peptide Name   #4330 derived from HIV-1 integrase

Sequence  KGEAMHGQVDCSPGIWQLDC

Sequence Length  20

UniProt ID  P04587 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  Assay for the enzymatic activities of RT

Activity 

• [Ref.17257575]HIV-1:inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(IC50=4 μM);inhibition of reverse transcriptase(DNA-dependent DNA polymerase) activity(IC50=6.8 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Reverse Transcriptase

Mechanism  The peptide could bind the reverse transcriptase and inhibits its DNA-polymerase activity and thus inhibits virus replication.

PDB ID  None

Predicted Structure Download  DRAVPe01578

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.

Pubmed ID   17257575

Reference   Arch Biochem Biophys. 2007 Feb 15;458(2):202-12.

Author   Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.

DOI   10.1016/j.abb.2006.12.007