General Information
DRAVP ID DRAVPe01580
Peptide Name #5650 derived from HIV-1 integrase
Sequence KCQLKGEAMHGQVDC
Sequence Length 15
UniProt ID P04587
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Assay for the enzymatic activities of RT
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Reverse Transcriptase
Mechanism The peptide could bind the reverse transcriptase and inhibits its DNA-polymerase activity and thus inhibits virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01580
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C66H111N21O22S3
Absent amino acids FINPRSTWY
Common amino acids CGKQ
Mass 1646.91
Pl 6.73
Basic residues 3
Acidic residues 2
Hydrophobic residues 3
Net charge 1
Boman Index -2481
Hydrophobicity -60.67
Aliphatic Index 52
Half Life
Extinction Coefficient cystines 125
Absorbance 280nm 8.93
Polar residues 4
Literature Information
Literature 1
Title Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.
Pubmed ID 17257575
Reference Arch Biochem Biophys. 2007 Feb 15;458(2):202-12.
Author Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.