General Information


DRAVP ID  DRAVPe01580

Peptide Name   #5650 derived from HIV-1 integrase

Sequence  KCQLKGEAMHGQVDC

Sequence Length  15

UniProt ID  P04587 

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Assay for the enzymatic activities of RT

Activity 

  • [Ref.17257575]HIV-1: inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(63± 3% residual DNA polymerase activity at 30 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Reverse Transcriptase

Mechanism  The peptide could bind the reverse transcriptase and inhibits its DNA-polymerase activity and thus inhibits virus replication.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01580

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C66H111N21O22S3

Absent amino acids  FINPRSTWY

Common amino acids  CGKQ

Mass  1646.91

Pl  6.73

Basic residues  3

Acidic residues  2

Hydrophobic residues  3

Net charge  1

Boman Index  -2481

Hydrophobicity  -60.67

Aliphatic Index  52

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  125

Absorbance 280nm  8.93

Polar residues  4



Literature Information


Literature 1

Title   Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.

Pubmed ID   17257575

Reference   Arch Biochem Biophys. 2007 Feb 15;458(2):202-12.

Author   Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.

DOI   10.1016/j.abb.2006.12.007