General Information

General Information

DRAVP ID DRAVPe01582

Peptide Name #5652 derived from HIV-1 integrase

Sequence MHGQVDCSPGIWQLD

Sequence Length 15

UniProt ID P04587

Source Synthetic construct

Activity Information

Target Organism HIV

Assay Assay for the enzymatic activities of RT

Activity

[Ref.17257575]HIV-1: inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(79 ± 3% residual DNA polymerase activity at 30 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Reverse Transcriptase

Mechanism The peptide could bind the reverse transcriptase and inhibits its DNA-polymerase activity and thus inhibits virus replication.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01582

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C72H108N20O23S2

Absent amino acids AEFKNRTY

Common amino acids DGQ

Mass 1685.89

Pl 4.2

Basic residues 1

Acidic residues 2

Hydrophobic residues 4

Net charge -1

Boman Index -1486

Hydrophobicity -29.33

Aliphatic Index 71.33

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 392.86

Polar residues 4

Literature Information

Literature 1

Title Inhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase.

Pubmed ID 17257575

Reference Arch Biochem Biophys. 2007 Feb 15;458(2):202-12.

Author Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A.

DOI 10.1016/j.abb.2006.12.007