General Information


DRAVP ID  DRAVPe01601

Peptide Name   Rex (1-21)

Sequence  MPKTRRRPRRSQRKRPPTPWP

Sequence Length  21

UniProt ID  P0C207 

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  MAGI assay

Activity 

  • [Ref.20580677]HIV-1 IIIB:inhibition of virus replication in PM1-CCR5 cells(EC50>10 μM);
  • HIV-1 Bal:inhibition of virus replication in PM1-CCR5 cells(EC50>10 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  Peptide derived from the RNA-binding domain of HIV-1 Rev can act as dual-target inhibitors that inhibit HIV-1 entry and viral production in the early and late phases of replication. 



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01601

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C116H198N46O26S

Absent amino acids  ACDEFGHILNVY

Common amino acids  R

Mass  2685.2

Pl  12.78

Basic residues  9

Acidic residues  0

Hydrophobic residues  1

Net charge  9

Boman Index  -12494

Hydrophobicity  -255.24

Aliphatic Index  0

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  5500

Absorbance 280nm  275

Polar residues  3



Literature Information


Literature 1

Title   Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

Pubmed ID   20580677

Reference   Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8.

Author   Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M.

DOI   10.1016/j.biocel.2010.05.005