General Information

General Information

DRAVP ID DRAVPe01601

Peptide Name Rex (1-21)

Sequence MPKTRRRPRRSQRKRPPTPWP

Sequence Length 21

UniProt ID P0C207

Source Synthetic construct

Activity Information

Target Organism HIV

Assay MAGI assay

Activity

[Ref.20580677]HIV-1 IIIB:inhibition of virus replication in PM1-CCR5 cells(EC50>10 μM);
HIV-1 Bal:inhibition of virus replication in PM1-CCR5 cells(EC50>10 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism Peptide derived from the RNA-binding domain of HIV-1 Rev can act as dual-target inhibitors that inhibit HIV-1 entry and viral production in the early and late phases of replication.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01601

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C116H198N46O26S

Absent amino acids ACDEFGHILNVY

Common amino acids R

Mass 2685.2

Pl 12.78

Basic residues 9

Acidic residues 0

Hydrophobic residues 1

Net charge 9

Boman Index -12494

Hydrophobicity -255.24

Aliphatic Index 0

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 275

Polar residues 3

Literature Information

Literature 1

Title Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

Pubmed ID 20580677

Reference Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8.

Author Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M.

DOI 10.1016/j.biocel.2010.05.005