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General Information
DRAVP ID DRAVPe01601
Peptide Name Rex (1-21)
Sequence MPKTRRRPRRSQRKRPPTPWP
Sequence Length 21
UniProt ID P0C207
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not available
Activity Information
Target Organism HIV
Assay MAGI assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism Peptide derived from the RNA-binding domain of HIV-1 Rev can act as dual-target inhibitors that inhibit HIV-1 entry and viral production in the early and late phases of replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01601
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C116H198N46O26S
Absent amino acids ACDEFGHILNVY
Common amino acids R
Mass 2685.2
Pl 12.78
Basic residues 9
Acidic residues 0
Hydrophobic residues 1
Net charge 9
Boman Index -12494
Hydrophobicity -255.24
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 275
Polar residues 3
Literature Information
Literature 1
Title Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.
Pubmed ID 20580677
Reference Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8.
Author Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.