DRAVP ID  DRAVPe01603

Peptide Name   RSG-P2G4

Sequence  RPRGRRGSRPSGAERRRRRAAAA

Sequence Length  23

UniProt ID  None 

Source  Synthetic construct

Target Organism  HIV

Assay  MAGI assay

Activity 

• [Ref.20580677]HIV-1 IIIB:inhibition of virus replication in PM1-CCR5 cells(EC50=2.2±0.51 μM);
• HIV-1 Bal:inhibition of virus replication in PM1-CCR5 cells(EC50>10 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  Peptide derived from the RNA-binding domain of HIV-1 Rev can act as dual-target inhibitors that inhibit HIV-1 entry and viral production in the early and late phases of replication. 

PDB ID  None

Predicted Structure Download  DRAVPe01603

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.

Pubmed ID   20580677

Reference   Int J Biochem Cell Biol. 2010 Sep;42(9):1482-8.

Author   Shimane K, Kodama EN, Nakase I, Futaki S, Sakurai Y, Sakagami Y, Li X, Hattori T, Sarafianos SG, Matsuoka M.

DOI   10.1016/j.biocel.2010.05.005