General Information

General Information

DRAVP ID DRAVPe01606

Peptide Name CCR5 ECL2 (170-189)

Sequence QKEGLHYTCSSHFPYSQYQF

Sequence Length 20

UniProt ID P51681

Source Synthetic construct

Activity Information

Target Organism HIV

Assay HIV neutralization assay

Activity

[Ref.22403408]HIV-1 YU2:inhibition of virus infection in TZM-bl cells(IC50=237 ± 31 μM);
HIV-1 BaL26:inhibition of virus infection in TZM-bl cells(IC50=612± 21 μM);
HIV-1 HxB2:inhibition of virus infection in TZM-bl cells(IC50=374±28 μM);
HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50=600±24 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target gp120

Mechanism The peptide binds gp120 and inhibits virus entry.

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01606

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C112H152N28O33S

Absent amino acids ADIMNRVW

Common amino acids QSY

Mass 2450.67

Pl 6.91

Basic residues 3

Acidic residues 1

Hydrophobic residues 3

Net charge 2

Boman Index -3839

Hydrophobicity -107

Aliphatic Index 19.5

Half Life

Mammalian:0.8 hour
Yeast:10 min
E.coli:>10 hour

Extinction Coefficient cystines 4470

Absorbance 280nm 235.26

Polar residues 9

Literature Information

Literature 1

Title Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.

Pubmed ID 22403408

Reference J Biol Chem. 2012 Apr 27;287(18):15076-86.

Author Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA.

DOI 10.1074/jbc.M111.332361