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General Information
DRAVP ID DRAVPe01613
Peptide Name N-[RLLR]3
Sequence APKAMRLLRRLLRRLLR
Sequence Length 17
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not available
Activity Information
Target Organism HSV
Assay plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The anti-HSV1 activity of apoEdp involves inhibition of virus particle attachment to cells, with this likely being related to the derivation of this peptide from the apoE HSPG/LDLR binding region.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01613
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C94H178N36O18S
Absent amino acids CDEFGHINQSTVWY
Common amino acids LR
Mass 2132.74
Pl 12.7
Basic residues 7
Acidic residues 0
Hydrophobic residues 8
Net charge 7
Boman Index -5958
Hydrophobicity -24.71
Aliphatic Index 149.41
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity.
Pubmed ID 17681018
Reference FEBS J. 2007 Sep;274(17):4511-25.
Author Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.