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General Information
DRAVP ID DRAVPe01621
Peptide Name None
Sequence HCKFAW
Sequence Length 6
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay integrase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target integrase
Mechanism The peptide may inhibit integrase-mediated 3'-processing and integration, which is useful for inhibiting virus replication.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01621
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C38H50N10O7S
Absent amino acids DEGILMNPQRSTVY
Common amino acids ACFHKW
Mass 790.94
Pl 8.23
Basic residues 2
Acidic residues 0
Hydrophobic residues 3
Net charge 2
Boman Index -181
Hydrophobicity -15
Aliphatic Index 16.67
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 1
Literature Information
Literature 1
Title Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.
Pubmed ID 8524782
Reference Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60.
Author Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.