To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01628
Peptide Name P2(ACE2 (12-20))
Sequence DKFNHEAED
Sequence Length 9
UniProt ID Q9BYF1
Source Synthetic construct(derived from angiotensin-converting enzyme 2)
Activity Information
Target Organism SARS-CoV
Assay Pseudovirus infection assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target spike glycoprotein
Mechanism Virus entry into cells is mediated through interactions between spike (S) glycoprotein and angiotensin-converting enzyme 2 (ACE2), peptide derived from ACE2 could bind with spike glycoprotein and inhibits virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C46H65N13O19
Absent amino acids CGILMPQRSTVWY
Common amino acids DE
Mass 1104.1
Pl 4.31
Basic residues 2
Acidic residues 4
Hydrophobic residues 2
Net charge -2
Boman Index -4312
Hydrophobicity -222.22
Aliphatic Index 11.11
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor.
Pubmed ID 16510163
Reference Virology. 2006 Jun 20;350(1):15-25.
Author Han DP, Penn-Nicholson A, Cho MW.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.