General Information

General Information

DRAVP ID DRAVPe01639

Peptide Name DENV Envelope glycoprotein (340 – 354)

Sequence GQGKAHNGRLITANP

Sequence Length 15

UniProt ID Q5UB51 P17763

Source Synthetic construct(derived from DENV Envelope glycoprotein)

Activity Information

Target Organism DENV

Assay Focus-forming assay (FFA)

Activity

[Ref.30508603]DENV-1:inhibition of virus infection in Vero cells(83%±3.72% inhibition at 50 μM,IC50=33 μM);
DENV-2:inhibition of virus infection in Vero cells(IC50=10 μM);
DENV-3:inhibition of virus infection in Vero cells(60% inhibition at 20μM);
DENV-4:inhibition of virus infection in Vero cells(55% inhibition at 20μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.30508603]<20% cytotoxicity against Vero and C6/36 cells at 200 μM.

Binding Target E protein

Mechanism The peptide acts as inhibitors by binding to the E protein, suppressing its conformational changes, and preventing its binding to the cellular receptor, thereby inhibiting viral entry.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C64H108N24O20

Absent amino acids CDEFMSVWY

Common amino acids G

Mass 1533.71

Pl 11

Basic residues 3

Acidic residues 0

Hydrophobic residues 4

Net charge 3

Boman Index -3024

Hydrophobicity -91.33

Aliphatic Index 65.33

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Literature Information

Literature 1

Title In vitro analysis of synthetic peptides in blocking the entry of dengue virus.

Pubmed ID 30508603

Reference Virus Res. 2019 Jan 15;260:142-150.

Author John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P.

DOI 10.1016/j.virusres.2018.11.016