DRAVP ID  DRAVPe01641

Peptide Name   Alloferon-1 [H1R]

Sequence  RGVSGHGQHGVHG

Sequence Length  13

UniProt ID  P83412 

Source  Synthetic construct

Target Organism  HHV,CBV2

Assay  Antiviral assay(cytopathic effect)

Activity 

• [Ref.21766388]HHV-1 McIntyre strain:inhibition of virus replication in Vero cells(IC50=321.10 µg/ml);
• HHV-1:inhibition of virus replication in Vero cells(IC50=277.50 µg/ml);inhibition of virus replication in HEp-2 cells(IC50=602.18 µg/ml);
• Coxsackie virus 971 PT(971 PT CVB2):inhibition of virus replication in LLC-MK2 cells(IC50=577.73 µg/ml);inhibition of virus replication in Hep-2 cells(IC50=167.71 µg/ml);
• CVB2:inhibition of virus replication in LLC-MK2 cells(IC50=355.18 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.21766388]No cytotoxicity against Vero cells,LLC-MK2 cells and Hep-2 cells up to 143.75 µg/ml.

Binding Target  Not found

Mechanism  The peptide may inhibit the replication of DNA and RNA viruses.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Further studies on the antiviral activity of alloferon and its analogues.

Pubmed ID   21766388

Reference   J Pept Sci. 2011 Nov;17(11):715-9.

Author   Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D.

DOI   10.1002/psc.1388