DRAVP ID  DRAVPe01641

Peptide Name   Alloferon-1 [H1R]

Sequence  RGVSGHGQHGVHG

Sequence Length  13

UniProt ID  P83412 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HHV,CBV2

Assay  Antiviral assay(cytopathic effect)

Activity 

• [Ref.21766388]HHV-1 McIntyre strain:inhibition of virus replication in Vero cells(IC50=321.10 µg/ml);
• HHV-1:inhibition of virus replication in Vero cells(IC50=277.50 µg/ml);inhibition of virus replication in HEp-2 cells(IC50=602.18 µg/ml);
• Coxsackie virus 971 PT(971 PT CVB2):inhibition of virus replication in LLC-MK2 cells(IC50=577.73 µg/ml);inhibition of virus replication in Hep-2 cells(IC50=167.71 µg/ml);
• CVB2:inhibition of virus replication in LLC-MK2 cells(IC50=355.18 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.21766388]No cytotoxicity against Vero cells,LLC-MK2 cells and Hep-2 cells up to 143.75 µg/ml.

Binding Target  Not found

Mechanism  The peptide may inhibit the replication of DNA and RNA viruses.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Further studies on the antiviral activity of alloferon and its analogues.

Pubmed ID   21766388

Reference   J Pept Sci. 2011 Nov;17(11):715-9.

Author   Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D.

DOI   10.1002/psc.1388