General Information

General Information

DRAVP ID DRAVPe01642

Peptide Name Alloferon-1 [H1A]

Sequence AGVSGHGQHGVHG

Sequence Length 13

UniProt ID P83412

Source Synthetic construct

Activity Information

Target Organism HHV,CBV2

Assay Antiviral assay(cytopathic effect)

Activity

[Ref.21766388]Coxsackie virus 971 PT(971 PT CVB2):inhibition of virus replication in LLC-MK2 cells(IC50=358.00 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.21766388]No cytotoxicity against Vero cells,LLC-MK2 cells and Hep-2 cells up to 187.50 µg/ml.

Binding Target Not found

Mechanism The peptide may inhibit the replication of DNA and RNA viruses.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C49H74N20O16

Absent amino acids CDEFIKLMNPRTWY

Common amino acids G

Mass 1199.25

Pl 7.06

Basic residues 3

Acidic residues 0

Hydrophobic residues 3

Net charge 3

Boman Index -833

Hydrophobicity -43.85

Aliphatic Index 52.31

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Literature Information

Literature 1

Title Further studies on the antiviral activity of alloferon and its analogues.

Pubmed ID 21766388

Reference J Pept Sci. 2011 Nov;17(11):715-9.

Author Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D.

DOI 10.1002/psc.1388