General Information

General Information

DRAVP ID DRAVPe01642

Peptide Name Alloferon-1 [H1A]

Sequence AGVSGHGQHGVHG

Sequence Length 13

UniProt ID P83412

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HHV,CBV2

Assay Antiviral assay(cytopathic effect)

Activity

[Ref.21766388]Coxsackie virus 971 PT(971 PT CVB2):inhibition of virus replication in LLC-MK2 cells(IC50=358.00 µg/ml).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.21766388]No cytotoxicity against Vero cells,LLC-MK2 cells and Hep-2 cells up to 187.50 µg/ml.

Binding Target Not found

Mechanism The peptide may inhibit the replication of DNA and RNA viruses.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C49H74N20O16

Absent amino acids CDEFIKLMNPRTWY

Common amino acids G

Mass 1199.25

Pl 7.06

Basic residues 3

Acidic residues 0

Hydrophobic residues 3

Net charge 3

Boman Index -833

Hydrophobicity -43.85

Aliphatic Index 52.31

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Literature Information

Literature 1

Title Further studies on the antiviral activity of alloferon and its analogues.

Pubmed ID 21766388

Reference J Pept Sci. 2011 Nov;17(11):715-9.

Author Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D.

DOI 10.1002/psc.1388