To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01644
Peptide Name Peptide 4(lactoferrin 441–454)
Sequence KANEGLTWNSLKDK
Sequence Length 14
UniProt ID P24627
Source Synthetic construct
Activity Information
Target Organism Influenza virus
Assay Neutralization assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target hemagglutinin (HA)
Mechanism Hemagglutinin is the major glycoprotein component of the viral envelope along with neuraminidase (NA), peptide derived from Lactoferrin binds Influenza A virus hemagglutinin (HA) inhibiting the hemagglutination and infection of major virus subtypes.
Structure Information
PDB ID 3IB0
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C70H114N20O23
Absent amino acids CFHIMPQRVY
Common amino acids K
Mass 1603.8
Pl 8.5
Basic residues 3
Acidic residues 2
Hydrophobic residues 4
Net charge 1
Boman Index -3651
Hydrophobicity -136.43
Aliphatic Index 62.86
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 423.08
Polar residues 5
Literature Information
Literature 1
Title Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.
Pubmed ID 28878220
Reference Sci Rep. 2017 Sep 6;7(1):10593.
Author Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.