General Information

General Information

DRAVP ID DRAVPe01645

Peptide Name Peptide 6(lactoferrin 552-563)

Sequence TNGESTADWAKN

Sequence Length 12

UniProt ID P24627

Source Synthetic construct

Activity Information

Target Organism Influenza virus

Assay Neutralization assay

Activity

[Ref.28878220]A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=400 ±0.02 pM);
A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells(EC50=50.000 ± 230 pM);
A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells(EC50=10.000± 120 pM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target hemagglutinin (HA)

Mechanism Hemagglutinin is the major glycoprotein component of the viral envelope along with neuraminidase (NA), peptide derived from Lactoferrin binds Influenza A virus hemagglutinin (HA) inhibiting the hemagglutination and infection of major virus subtypes.

Structure Information

PDB ID 3IB0

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C53H80N16O22

Absent amino acids CFHILMPQRVY

Common amino acids ANT

Mass 1293.31

Pl 4.37

Basic residues 1

Acidic residues 2

Hydrophobic residues 3

Net charge -1

Boman Index -3601

Hydrophobicity -148.33

Aliphatic Index 16.67

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 500

Polar residues 6

Literature Information

Literature 1

Title Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

Pubmed ID 28878220

Reference Sci Rep. 2017 Sep 6;7(1):10593.

Author Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.

DOI 10.1038/s41598-017-10492-x