General Information


DRAVP ID  DRAVPe01649

Peptide Name   Peptide 16(lactoferrin 418-425)

Sequence  SKHSSLDC

Sequence Length  8

UniProt ID  P24627 

Source  Synthetic construct



Activity Information


Target Organism  Influenza virus

Assay  Neutralization assay

Activity 

  • [Ref.28878220]A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=80 ± 0.19 pM);
  • A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells(EC50=0.1 ± 0.001 pM);
  • A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells(EC50=5.0 ± 0.45 pM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  hemagglutinin (HA)

Mechanism  Hemagglutinin is the major glycoprotein component of the viral envelope along with neuraminidase (NA), peptide derived from Lactoferrin binds Influenza A virus hemagglutinin (HA) inhibiting the hemagglutination and infection of major virus subtypes.



Structure Information


PDB ID  3IB0 

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C34H57N11O14S

Absent amino acids  AEFGIMNPQRTVWY

Common amino acids  S

Mass  875.95

Pl  6.46

Basic residues  2

Acidic residues  1

Hydrophobic residues  1

Net charge  1

Boman Index  -2293

Hydrophobicity  -83.75

Aliphatic Index  48.75

Half Life 

  •     Mammalian:1.9 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title   Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

Pubmed ID   28878220

Reference   Sci Rep. 2017 Sep 6;7(1):10593.

Author   Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.

DOI   10.1038/s41598-017-10492-x