General Information

General Information

DRAVP ID DRAVPe01651

Peptide Name Peptide 17(lactoferrin 418–421)

Sequence SKHS

Sequence Length 4

UniProt ID P24627

Source Synthetic construct

Activity Information

Target Organism Influenza virus

Assay Neutralization assay

Activity

[Ref.28878220]A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=3 ± 0.61 pM);
A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells(EC50=0.048 ± 0.0012 pM);
A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells(EC50=5.0 ± 0.02 pM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target hemagglutinin (HA)

Mechanism Hemagglutinin is the major glycoprotein component of the viral envelope along with neuraminidase (NA), peptide derived from Lactoferrin binds Influenza A virus hemagglutinin (HA) inhibiting the hemagglutination and infection of major virus subtypes.

Structure Information

PDB ID 3IB0

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Acylation

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C18H31N7O7

Absent amino acids ACDEFGILMNPQRTVWY

Common amino acids S

Mass 457.49

Pl 8.49

Basic residues 2

Acidic residues 0

Hydrophobic residues 0

Net charge 2

Boman Index -1701

Hydrophobicity -217.5

Aliphatic Index 0

Half Life

Mammalian:1.9 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

Pubmed ID 28878220

Reference Sci Rep. 2017 Sep 6;7(1):10593.

Author Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.

DOI 10.1038/s41598-017-10492-x

Literature 2

Title Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies.

Pubmed ID 34681184

Reference Pharmaceuticals (Basel). 2021 Sep 23;14(10):959.

Author Scala MC, Agamennone M, Pietrantoni A, Di Sarno V, Bertamino A, Superti F, Campiglia P, Sala M.

DOI 10.3390/ph14100959