To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01720
Peptide Name JEV Ep (424–445)
Sequence AWDFGSIGGVFNSIGRAVHQVF
Sequence Length 22
UniProt ID P0DOH7
Source Synthetic construct
Activity Information
Target Organism JEV, ZIKV
Assay qRT-PCR, western blotting, the plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target membrane
Mechanism The peptide prevented JEV infection in mice by reducing viral load and the inflammatory response in the brain, thereby improving the survival rate.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C110H158N30O29
Absent amino acids CEKLMPTY
Common amino acids G
Mass 2364.65
Pl 6.79
Basic residues 2
Acidic residues 1
Hydrophobic residues 11
Net charge 1
Boman Index -667
Hydrophobicity 51.36
Aliphatic Index 84.09
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 261.9
Polar residues 7
Literature Information
Literature 1
Title Antiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses.
Pubmed ID 28232248
Reference Antiviral Res. 2017 May;141:140-149.
Author Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.