To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01726
Peptide Name N46eg(SARS-CoV (902-947)[K2N,I4S,N9Q,A11E,Q16N,S18V,S23N,A25S,V32D,A37N,A39S,V44Q,Q46E])
Sequence QNQSANQFQKEISQINEVLTTTNTSLGKLQDDVNQNNQSLNTLQKE
Sequence Length 46
UniProt ID P59594
Source Synthetic construct
Activity Information
Target Organism SARS-CoV
Assay cell fusion inhibition assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism Binding to the HR2 region and blocking the formation of a 6-helix bundle during the fusion step of virus entry, thus inhibiting virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C216H356N66O83
Absent amino acids CHMPRWY
Common amino acids Q
Mass 5205.59
Pl 4.51
Basic residues 3
Acidic residues 5
Hydrophobic residues 11
Net charge -2
Boman Index -13570
Hydrophobicity -119.13
Aliphatic Index 74.13
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 18
Literature Information
Literature 1
Title Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors.
Pubmed ID 18983873
Reference Antiviral Res. 2009 Jan;81(1):82-7.
Author Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.