General Information

General Information

DRAVP ID DRAVPe01727

Peptide Name SARS-CoV-S (215-232), peptide 9626

Sequence TLKPIFKLPLGINITNFR

Sequence Length 18

UniProt ID P59594

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism SARS-CoV PsV

Assay western blot

Activity

[Ref.19853613]SARS-COV: inhibition of SARS-CoV/HIV PsV virus infection in 293T/ACE2 cells (IC50=11µM); inhibition of SARS-CoV/HIV PsV virus entry in 293T/ACE2 cells(80% at 50µM)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target not found

Mechanism Presumably inhibit virus entry by binding to Spike protein, hACE2, or an unknown co-receptor.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C100H165N25O23

Absent amino acids ACDEHMQSVWY

Common amino acids IL

Mass 2085.56

Pl 11.17

Basic residues 3

Acidic residues 0

Hydrophobic residues 8

Net charge 3

Boman Index -802

Hydrophobicity 34.44

Aliphatic Index 130

Half Life

Mammalian:7.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Identification of a new region of SARS-CoV S protein critical for viral entry.

Pubmed ID 19853613

Reference J Mol Biol. 2009 Dec 11;394(4):600-5.

Author Guo Y, Tisoncik J, McReynolds S, Farzan M, Prabhakar BS, Gallagher T, Rong L, Caffrey M.

DOI 10.1016/j.jmb.2009.10.032