General Information

General Information

DRAVP ID DRAVPe01729

Peptide Name SARS-CoV (864-886)

Sequence ATAGWTFGAGAALQIPFAMQMAY

Sequence Length 23

UniProt ID Q19QX0

Source Synthetic construct

Activity Information

Target Organism SARS-CoV

Assay Plaque reduction assay

Activity

[Ref.16616792]SARS-CoV: inhibition of virus infection in Vero-E6 cells(39% inhibition at 30 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.16616792]No cytotoxic at a concentration of 30 μM on Vero-E6 cells

Binding Target cell membrane

Mechanism inhibits viral entry through coiled coil interactions.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C110H160N26O29S2

Absent amino acids CDEHKNRSV

Common amino acids A

Mass 2374.76

Pl 5.57

Basic residues 0

Acidic residues 0

Hydrophobic residues 12

Net charge 0

Boman Index 2196

Hydrophobicity 73.48

Aliphatic Index 64.35

Half Life

Mammalian:4.4 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 317.73

Polar residues 6

Literature Information

Literature 1

Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.

Pubmed ID 16616792

Reference Virus Res. 2006 Sep;120(1-2):146-55.

Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.

DOI 10.1016/j.virusres.2006.03.001