General Information

General Information

DRAVP ID DRAVPe01730

Peptide Name SARS-CoV (1028–1049)[Y1049W]

Sequence GYHLMSFPQAAPHGVVFLHVTW

Sequence Length 22

UniProt ID Q19QX0

Source Synthetic construct

Activity Information

Target Organism SARS-CoV

Assay Plaque reduction assay

Activity

[Ref.16616792]SARS-CoV: inhibition of virus infection in Vero-E6 cells(90% inhibition at 30 μM,IC50~2 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.16616792]No cytotoxic at a concentration of 30 μM on Vero-E6 cells

Binding Target cell membrane

Mechanism inhibits viral entry through coiled coil interactions.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C120H166N30O26S

Absent amino acids CDEIKNR

Common amino acids HV

Mass 2607.98

Pl 7.02

Basic residues 3

Acidic residues 0

Hydrophobic residues 10

Net charge 3

Boman Index 1247

Hydrophobicity 45.65

Aliphatic Index 80.43

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 317.73

Polar residues 5

Literature Information

Literature 1

Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.

Pubmed ID 16616792

Reference Virus Res. 2006 Sep;120(1-2):146-55.

Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.

DOI 10.1016/j.virusres.2006.03.001