To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01732
Peptide Name AAC-SARS-CoV (1170–1194)
Sequence AACEVAKNLNESLIDLQELGKYEQYIKW
Sequence Length 28
UniProt ID Q19QX0
Source Synthetic construct
Activity Information
Target Organism SARS-CoV
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target cell membrane
Mechanism inhibits viral entry through coiled coil interactions.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C147H230N36O46S
Absent amino acids FHMPRT
Common amino acids EL
Mass 3269.72
Pl 4.59
Basic residues 3
Acidic residues 5
Hydrophobic residues 11
Net charge -2
Boman Index -3711
Hydrophobicity -41.43
Aliphatic Index 104.64
Half Life
Extinction Coefficient cystines 8480
Absorbance 280nm 314.07
Polar residues 7
Literature Information
Literature 1
Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.
Pubmed ID 16616792
Reference Virus Res. 2006 Sep;120(1-2):146-55.
Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.