General Information

General Information

DRAVP ID DRAVPe01734

Peptide Name MHV (1144–1162)

Sequence GYFVQDDGEWKFTGSSYYY

Sequence Length 19

UniProt ID P11224

Source Synthetic construct

Activity Information

Target Organism MHV

Assay Plaque reduction assay

Activity

[Ref.16616792]MHV(murine hepatitis virus): inhibition of virus infection in L2 cells(98% inhibition at 30 Μm, IC50=4 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.16616792]No cytotoxic at a concentration of 30 μM on L2cells

Binding Target cell membrane

Mechanism inhibits viral entry through coiled coil interactions.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C110H138N22O34

Absent amino acids ACHILMNPR

Common amino acids Y

Mass 2312.43

Pl 4.03

Basic residues 1

Acidic residues 3

Hydrophobic residues 4

Net charge -2

Boman Index -3012

Hydrophobicity -93.16

Aliphatic Index 15.26

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 11460

Absorbance 280nm 636.67

Polar residues 10

Literature Information

Literature 1

Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.

Pubmed ID 16616792

Reference Virus Res. 2006 Sep;120(1-2):146-55.

Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.

DOI 10.1016/j.virusres.2006.03.001