General Information


DRAVP ID  DRAVPe01734

Peptide Name   MHV (1144–1162)

Sequence  GYFVQDDGEWKFTGSSYYY

Sequence Length  19

UniProt ID  P11224 

Source  Synthetic construct



Activity Information


Target Organism  MHV

Assay  Plaque reduction assay

Activity 

  • [Ref.16616792]MHV(murine hepatitis virus): inhibition of virus infection in L2 cells(98% inhibition at 30 Μm, IC50=4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.16616792]No cytotoxic at a concentration of 30 μM on L2cells

Binding Target  cell membrane

Mechanism  inhibits viral entry through coiled coil interactions.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C110H138N22O34

Absent amino acids  ACHILMNPR

Common amino acids  Y

Mass  2312.43

Pl  4.03

Basic residues  1

Acidic residues  3

Hydrophobic residues  4

Net charge  -2

Boman Index  -3012

Hydrophobicity  -93.16

Aliphatic Index  15.26

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  11460

Absorbance 280nm  636.67

Polar residues  10



Literature Information


Literature 1

Title   Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.

Pubmed ID   16616792

Reference   Virus Res. 2006 Sep;120(1-2):146-55.

Author   Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.

DOI   10.1016/j.virusres.2006.03.001