General Information
DRAVP ID DRAVPe01734
Peptide Name MHV (1144–1162)
Sequence GYFVQDDGEWKFTGSSYYY
Sequence Length 19
UniProt ID P11224
Source Synthetic construct
Activity Information
Target Organism MHV
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target cell membrane
Mechanism inhibits viral entry through coiled coil interactions.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C110H138N22O34
Absent amino acids ACHILMNPR
Common amino acids Y
Mass 2312.43
Pl 4.03
Basic residues 1
Acidic residues 3
Hydrophobic residues 4
Net charge -2
Boman Index -3012
Hydrophobicity -93.16
Aliphatic Index 15.26
Half Life
Extinction Coefficient cystines 11460
Absorbance 280nm 636.67
Polar residues 10
Literature Information
Literature 1
Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.
Pubmed ID 16616792
Reference Virus Res. 2006 Sep;120(1-2):146-55.
Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.