General Information


DRAVP ID  DRAVPe01735

Peptide Name   SARS-Cov-S (899-926)

Sequence  YENQKQIANQFNKAISQIQESLTTTSTA

Sequence Length  28

UniProt ID  P59594 

Source  Synthetic construct



Activity Information


Target Organism  SARS-CoV PsV

Assay  HIV‐luc/SARS Pseudotyped Virus Entry Inhibition Assay

Activity 

  • [Ref.18442051]SARS-CoV PsV: inhibition of HIV-luc/SARS PsV infection in Vero-E6 cells (EC50=1.16μM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C135H218N38O49

Absent amino acids  CDGHMPRVW

Common amino acids  Q

Mass  3157.44

Pl  6.14

Basic residues  2

Acidic residues  2

Hydrophobic residues  8

Net charge  0

Boman Index  -6487

Hydrophobicity  -85

Aliphatic Index  66.43

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  1490

Absorbance 280nm  55.19

Polar residues  11



Literature Information


Literature 1

Title   Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors.

Pubmed ID   18442051

Reference   J Cell Biochem. 2008 Aug 15;104(6):2335-47.

Author   Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM.

DOI   10.1002/jcb.21790