General Information


DRAVP ID  DRAVPe01736

Peptide Name   SARS-Cov-S (1145-1192)

Sequence  DVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYI

Sequence Length  48

UniProt ID  P59594 

Source  Synthetic construct



Activity Information


Target Organism  SARS-CoV PsV

Assay  HIV‐luc/SARS Pseudotyped Virus Entry Inhibition Assay

Activity 

  • [Ref.18442051]SARS-CoV PsV: inhibition of HIV-luc/SARS PsV infection in Vero-E6 cells (EC50=2.15μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C235H384N62O82

Absent amino acids  CFHMPTW

Common amino acids  IL

Mass  5390

Pl  4.11

Basic residues  4

Acidic residues  10

Hydrophobic residues  18

Net charge  -6

Boman Index  -8788

Hydrophobicity  -31.67

Aliphatic Index  125.83

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  2980

Absorbance 280nm  63.4

Polar residues  13



Literature Information


Literature 1

Title   Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors.

Pubmed ID   18442051

Reference   J Cell Biochem. 2008 Aug 15;104(6):2335-47.

Author   Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM.

DOI   10.1002/jcb.21790