General Information


DRAVP ID  DRAVPe01745

Peptide Name   P4(DENV-2 gp (613-627))

Sequence  CKIPFEIMDLEKRHV

Sequence Length  15

UniProt ID  P14340 

Source  Synthetic construct



Activity Information


Target Organism  DENV-2

Assay  Plaque assay

Activity 

  • [Ref.29709564]DENV-2(dengue virus serotype 2): inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(70 ± 9% inhibition at 40 μM,44 ± 10% inhibition at 20 μM,40± 6% inhibition at 10 μM,IC50=19.08±2.52µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.29709564]No toxic effect on HUVEC(Human umbilical vein endothelial cells) at concentrations up to 100 µM

Binding Target  β3 integrin

Mechanism  might be involved in blocking viral entry via occupying the binding site in the receptor on the host cell(β3 integrin).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H136N22O22S2

Absent amino acids  AGNQSTWY

Common amino acids  EIK

Mass  1858.25

Pl  6.75

Basic residues  4

Acidic residues  3

Hydrophobic residues  5

Net charge  1

Boman Index  -2761

Hydrophobicity  -22.67

Aliphatic Index  97.33

Half Life 

  •     Mammalian:1.2 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin.

Pubmed ID   29709564

Reference   Antiviral Res. 2018 Jul;155:20-27.

Author   Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J.

DOI   10.1016/j.antiviral.2018.04.018