General Information

General Information

DRAVP ID DRAVPe01745

Peptide Name P4(DENV-2 gp (613-627))

Sequence CKIPFEIMDLEKRHV

Sequence Length 15

UniProt ID P14340

Source Synthetic construct

Activity Information

Target Organism DENV-2

Assay Plaque assay

Activity

[Ref.29709564]DENV-2(dengue virus serotype 2): inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(70 ± 9% inhibition at 40 μM,44 ± 10% inhibition at 20 μM,40± 6% inhibition at 10 μM,IC50=19.08±2.52µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.29709564]No toxic effect on HUVEC(Human umbilical vein endothelial cells) at concentrations up to 100 µM

Binding Target β3 integrin

Mechanism might be involved in blocking viral entry via occupying the binding site in the receptor on the host cell(β3 integrin).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C83H136N22O22S2

Absent amino acids AGNQSTWY

Common amino acids EIK

Mass 1858.25

Pl 6.75

Basic residues 4

Acidic residues 3

Hydrophobic residues 5

Net charge 1

Boman Index -2761

Hydrophobicity -22.67

Aliphatic Index 97.33

Half Life

Mammalian:1.2 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin.

Pubmed ID 29709564

Reference Antiviral Res. 2018 Jul;155:20-27.

Author Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J.

DOI 10.1016/j.antiviral.2018.04.018