General Information
DRAVP ID DRAVPe01745
Peptide Name P4(DENV-2 gp (613-627))
Sequence CKIPFEIMDLEKRHV
Sequence Length 15
UniProt ID P14340
Source Synthetic construct
Activity Information
Target Organism DENV-2
Assay Plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target β3 integrin
Mechanism might be involved in blocking viral entry via occupying the binding site in the receptor on the host cell(β3 integrin).
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C83H136N22O22S2
Absent amino acids AGNQSTWY
Common amino acids EIK
Mass 1858.25
Pl 6.75
Basic residues 4
Acidic residues 3
Hydrophobic residues 5
Net charge 1
Boman Index -2761
Hydrophobicity -22.67
Aliphatic Index 97.33
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin.
Pubmed ID 29709564
Reference Antiviral Res. 2018 Jul;155:20-27.
Author Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J.