General Information

General Information

DRAVP ID DRAVPe01746

Peptide Name P7(DENV-2 gp (662-674))

Sequence VEPGQLKLNWFKK

Sequence Length 13

UniProt ID P14340

Source Synthetic construct

Activity Information

Target Organism DENV-1, DENV-2

Assay Plaque assay

Activity

[Ref.29709564]DENV-2(dengue virus serotype 2): inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(65 ± 6% inhibition at 40 μM,55± 12% inhibition at 20 μM,41± 13% inhibition at 10 μM,IC50=12.86±5.96µM);
DENV-1(dengue virus serotype 1): inhibition of virus entry in HUVECs(human umbilical vein endothelial cells)(65 ± 12% inhibition at 40 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.29709564]No toxic effect on HUVEC(Human umbilical vein endothelial cells) at concentrations up to 100 µM

Binding Target β3 integrin

Mechanism might be involved in blocking viral entry via occupying the binding site in the receptor on the host cell(β3 integrin).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C76H119N19O18

Absent amino acids ACDHIMRSTY

Common amino acids K

Mass 1586.9

Pl 9.7

Basic residues 3

Acidic residues 1

Hydrophobic residues 5

Net charge 2

Boman Index -1551

Hydrophobicity -80.77

Aliphatic Index 82.31

Half Life

Mammalian:100 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 458.33

Polar residues 2

Literature Information

Literature 1

Title Peptides P4 and P7 derived from E protein inhibit entry of dengue virus serotype 2 via interacting with β3 integrin.

Pubmed ID 29709564

Reference Antiviral Res. 2018 Jul;155:20-27.

Author Cui X, Wu Y, Fan D, Gao N, Ming Y, Wang P, An J.

DOI 10.1016/j.antiviral.2018.04.018