DRAVP ID  DRAVPe01747

Peptide Name   HCV gp (548–562), E2-42

Sequence  QGSWFGCTWMNSTGF

Sequence Length  18

UniProt ID  Q99IB8 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HCV

Assay  HCV infection assay

Activity 

• [Ref.28638089]HCV(Hepatitis C virus): inhibition of HCVcc infection in Huh7.5/CD81 cells (IC50=1~5nM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.28638089]have no effect on the viability of Huh7.5-CD81 cells at concentrations of 10 nM

Binding Target  Envelope protein

Mechanism  Inhibits HCV entry at the post-attachment step and block cell-to-cell transmission, inhibit the late steps of HCV life cycle, such as HCV package and release.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.

Pubmed ID   28638089

Reference   A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.

Author   Yin P, Zhang L, Ye F, Deng Y, Lu S, Li YP, Zhang L, Tan W.

DOI   10.1038/s41598-017-04274-8