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General Information
DRAVP ID DRAVPe01749
Peptide Name HCV gp (692–706), E2-78
Sequence GLLHLHQNIVDVQYM
Sequence Length 15
UniProt ID Q99IB8
Source Synthetic construct
Activity Information
Target Organism HCV
Assay HCV infection assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Envelope protein
Mechanism Inhibits HCV entry at the post-attachment step and block cell-to-cell transmission, inhibit the late steps of HCV life cycle, such as HCV package and release.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C80H126N22O22S
Absent amino acids ACEFKPRSTW
Common amino acids L
Mass 1780.07
Pl 5.97
Basic residues 2
Acidic residues 1
Hydrophobic residues 6
Net charge 1
Boman Index -485
Hydrophobicity 27.33
Aliphatic Index 142.67
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 106.43
Polar residues 3
Literature Information
Literature 1
Title A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.
Pubmed ID 28638089
Reference A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2.
Author Yin P, Zhang L, Ye F, Deng Y, Lu S, Li YP, Zhang L, Tan W.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.