To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01752
Peptide Name T21N23
Sequence RIQQIEQKIHHIEQRIQQIEQRAIEAQQHLLQLTVWGIKQLQARIL
Sequence Length 46
UniProt ID None
Source Synthetic construct
Activity Information
Target Organism HIV-1
Assay Cell-cell fusion assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target gp41
Mechanism function as potent inhibitors of viral infection by forming a coiled-coil structure covalently stabilized by interchain disulfide bonds
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C249H417N79O68
Absent amino acids CDFMNPSY
Common amino acids Q
Mass 5605.54
Pl 9.97
Basic residues 9
Acidic residues 4
Hydrophobic residues 19
Net charge 5
Boman Index -9943
Hydrophobicity -52.83
Aliphatic Index 131.52
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 122.22
Polar residues 2
Literature Information
Literature 1
Title Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.
Pubmed ID 31932193
Reference Bioorg Med Chem. 2020 Feb 15;28(4):115214.
Author Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.