To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01753
Peptide Name T21N36
Sequence RIQQIEQKIHHIEQRIQQIEQRISGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL
Sequence Length 59
UniProt ID A1YNW7
Source Synthetic construct
Activity Information
Target Organism HIV-1
Assay Cell-cell fusion assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target gp41
Mechanism function as potent inhibitors of viral infection by forming a coiled-coil structure covalently stabilized by interchain disulfide bonds
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C312H526N100O87
Absent amino acids CDFMPY
Common amino acids Q
Mass 7070.23
Pl 10.78
Basic residues 10
Acidic residues 4
Hydrophobic residues 24
Net charge 6
Boman Index -12299
Hydrophobicity -45.25
Aliphatic Index 133.9
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 94.83
Polar residues 6
Literature Information
Literature 1
Title Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.
Pubmed ID 31932193
Reference Bioorg Med Chem. 2020 Feb 15;28(4):115214.
Author Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.