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General Information
DRAVP ID DRAVPe01757
Peptide Name DENV2 Ep (419-447)[A24G,I25A,Y26F]
Sequence AWDFGSLGGVFTSIGKALHQVFGGAFGAA
Sequence Length 29
UniProt ID Q9WDA6
Source Synthetic construct
Activity Information
Target Organism DENV-2
Assay Plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target low-pH endosome
Mechanism an initial, nonspecific interaction of the hydrophobicC terminus of the peptide inhibitor with the viral membranecarries it with the virion into the endosome, allowing aspecific interaction of the peptide with domain II as theprotein reconfigures, inhibiting the final zipping of thestem
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C135H194N34O36
Absent amino acids CEMNPRY
Common amino acids G
Mass 2869.23
Pl 6.79
Basic residues 2
Acidic residues 1
Hydrophobic residues 15
Net charge 1
Boman Index 1888
Hydrophobicity 71.03
Aliphatic Index 77.59
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 196.43
Polar residues 10
Literature Information
Literature 1
Title Peptide inhibitors of flavivirus entry derived from the E protein stem.
Pubmed ID 20881042
Reference J Virol. 2010 Dec;84(24):12549-54.
Author Schmidt AG, Yang PL, Harrison SC.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.