To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01767
Peptide Name SARS-CoV-2 HR1P
Sequence ANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ
Sequence Length 42
UniProt ID P0DTC2
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2
Assay Cell-cell fusion assay
Activity [Ref.32047258]SARS-CoV-2(No inhibition of cell-cell fusion up to 40 µM in Huh-7 cells,No inhibition of infection up to 40 µM in 293T/ACE2 cells)
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C187H314N56O65
Absent amino acids CEHMPRWY
Common amino acids AQ
Mass 4386.89
Pl 8.54
Basic residues 3
Acidic residues 2
Hydrophobic residues 17
Net charge 1
Boman Index -6039
Hydrophobicity -21.9
Aliphatic Index 100
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 14
Literature Information
Literature 1
Title Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein.
Pubmed ID 32047258
Reference Cell Mol Immunol. 2020 Jul;17(7):765-767.
Author Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.