To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01772
Peptide Name P7
Sequence SALEEQYKTFLDKFLHELEDLLYQLALAL
Sequence Length 29
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2
Assay plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C162H249N35O48
Absent amino acids CGIMNPRVW
Common amino acids L
Mass 3454.96
Pl 4.35
Basic residues 3
Acidic residues 6
Hydrophobic residues 14
Net charge -3
Boman Index -2210
Hydrophobicity 7.24
Aliphatic Index 131.38
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 106.43
Polar residues 4
Literature Information
Literature 1
Title Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection.
Pubmed ID 33580154
Reference Commun Biol. 2021 Feb 12;4(1):197.
Author Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.