DRAVP ID  DRAVPe01773

Peptide Name   P8

Sequence  SALEEQLKTFLDKFMHELEDLLYQLAL

Sequence Length  27

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  SARS-CoV-2

Assay  plaque assay

Activity 

• [Ref.33580154]SARS-CoV-2:91% inhibition of replication in Vero-E6 cells at 10 μM;inhibition of replication in Calu-3 cells(IC50=46 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.33580154]The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells.

Binding Target  Not found

Mechanism  The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection.

Pubmed ID   33580154

Reference   Commun Biol. 2021 Feb 12;4(1):197.

Author   Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O.

DOI   10.1038/s42003-021-01736-8