General Information

General Information

DRAVP ID DRAVPe01777

Peptide Name P3

Sequence ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQEL

Sequence Length 35

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism SARS-CoV-2

Assay Neutralizing assay

Activity

[Ref.32482145]HCoV-19:inhibition of HCoV-19 S mediated cell–cell fusion(EC50=0.72 μM);neutralizing activities against pseudotype HCoV-19 virus(EC50=0.32 μM);inhibition of authentic HCoV-19 virus infection in Vero E6 cells(EC50=0.58 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity No cytotoxicity information found in the reference(s) presented

Binding Target Not found

Mechanism Comment: No comments found on DRAMP database

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C168H287N47O58

Absent amino acids CFHMPTWY

Common amino acids ILN

Mass 3893.41

Pl 4.36

Basic residues 3

Acidic residues 6

Hydrophobic residues 15

Net charge -3

Boman Index -5930

Hydrophobicity -8.29

Aliphatic Index 142

Half Life

Mammalian:20 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 9

Literature Information

Literature 1

Title Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry.

Pubmed ID 32482145

Reference Emerg Microbes Infect. 2020 Dec;9(1):1238-1241.

Author Sun H, Li Y, Liu P, Qiao C, Wang X, Wu L, Liu K, Hu Y, Su C, Tan S, Zou S, Wu G, Yan J, Gao GF, Qi J, Wang Q.

DOI 10.1080/22221751.2020.1770631