General Information

General Information

DRAVP ID DRAVPe01791

Peptide Name VG

Sequence VALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSIGSGSGC

Sequence Length 42

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HPIV 3

Assay Plaque reduction assay

Activity

[Ref.28344321]Human parainfluenza viruse 3(HPIV 3): inhibition of virus infection in Vero cells(IC90=280 ± 247 nM,IC50=1 nM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.28344321]Vero cells: CC50>10000 nM.

Binding Target membrane

Mechanism Peptides derived from the HRC of paramyxovirus F proteins interfere with formation of the six-helix bundle in a dominant-negative manner by binding to the transiently exposed HRN coiled coil in the transient fusion intermediate, thereby inhibiting membrane fusion.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C193H323N55O66S

Absent amino acids FHMQTY

Common amino acids S

Mass 4502.08

Pl 5.05

Basic residues 6

Acidic residues 7

Hydrophobic residues 14

Net charge -1

Boman Index -8108

Hydrophobicity -32.38

Aliphatic Index 102.14

Half Life

Mammalian:100 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 134.15

Polar residues 14

Literature Information

Literature 1

Title Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

Pubmed ID 28344321

Reference Sci Rep. 2017 Mar 8;7:43610.

Author Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A

DOI 10.1038/srep43610