DRAVP ID  DRAVPe01796

Peptide Name   Chol-PEG4-VG

Sequence  XGSGSGVALDPIDISIVLNKAKSDLEESKEWIRRSNGKLDSI

Sequence Length  42

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  HPIV 3

Assay  Plaque reduction assay

Activity 

• [Ref.28344321]Human parainfluenza viruse 3(HPIV 3): inhibition of virus infection in Vero cells(IC90=0.1 ± 0.0001 nM,IC50<0.0007 nM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.28344321]Vero cells: CC50>10000 nM.

Binding Target  membrane

Mechanism  Peptides derived from the HRC of paramyxovirus F proteins interfere with formation of the six-helix bundle in a dominant-negative manner by binding to the transiently exposed HRN coiled coil in the transient fusion intermediate, thereby inhibiting membrane fusion.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  The 'X' at position 1 indicates cholesterol-PEG4 conjugated cysteine.

Stereochemistry  L

Literature 1

Title   Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

Pubmed ID   28344321

Reference   Sci Rep. 2017 Mar 8;7:43610.

Author   Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A

DOI   10.1038/srep43610