To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01800
Peptide Name U4
Sequence FINGRWDSQCHRFSNGAIACA
Sequence Length 21
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism Influenza A virus
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target HA
Mechanism Bind to the HA stem of group 1 influenza A virus.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C101H149N33O29S2
Absent amino acids EKLMPTVY
Common amino acids A
Mass 2353.62
Pl 8.08
Basic residues 3
Acidic residues 1
Hydrophobic residues 8
Net charge 2
Boman Index -4084
Hydrophobicity -21.43
Aliphatic Index 51.43
Half Life
Extinction Coefficient cystines 5625
Absorbance 280nm 281.25
Polar residues 8
Literature Information
Literature 1
Title Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants.
Pubmed ID 35259078
Reference Emerg Microbes Infect. 2022 Dec;11(1):926-937.
Author Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.