General Information

General Information

DRAVP ID DRAVPe01801

Peptide Name U5

Sequence IPLRGAFINGRWDSQCHRFS

Sequence Length 20

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism Influenza A virus

Assay Plaque reduction assay

Activity

[Ref.35259078]influenza A virus(H1N1): inhibition of viral replication in MDCK cells(IC50=12.9 μg/ml);

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target HA

Mechanism Bind to the HA stem of group 1 influenza A virus.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C105H158N34O27S

Absent amino acids EKMTVY

Common amino acids R

Mass 2360.68

Pl 10.26

Basic residues 4

Acidic residues 1

Hydrophobic residues 7

Net charge 3

Boman Index -4910

Hydrophobicity -47

Aliphatic Index 63.5

Half Life

Mammalian:20 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 289.47

Polar residues 6

Literature Information

Literature 1

Title Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants.

Pubmed ID 35259078

Reference Emerg Microbes Infect. 2022 Dec;11(1):926-937.

Author Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY.

DOI 10.1080/22221751.2022.2051753