General Information

General Information

DRAVP ID DRAVPe01805

Peptide Name 17BIPHE2

Sequence GXKRlVQRlKDXlRNLV

Sequence Length 17

UniProt ID No entry found

Source Synthetic construct(derived from LL-37)

Activity Information

Target Organism EBOV

Assay Plaque assay

Activity

[Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.71 µM);inhibition of viral infection in primary macrophages(IC50=5.6 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification The 'X' at position 2 and 12 indicates biphenylalanine.

Stereochemistry Mixed(D-Leu5, 9, 13)

Physicochemical Information

Formula C61H103N25O12

Absent amino acids ACEFHIMPSTWY

Common amino acids R

Mass 2030.86

Pl 11.72

Basic residues 5

Acidic residues 1

Hydrophobic residues 3

Net charge 4

Boman Index -6282

Hydrophobicity -117.65

Aliphatic Index 57.06

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.

Pubmed ID 32252021

Reference iScience. 2020 Apr 24;23(4):100999.

Author Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.

DOI 10.1016/j.isci.2020.100999