General Information


DRAVP ID  DRAVPe01805

Peptide Name   17BIPHE2

Sequence  GXKRlVQRlKDXlRNLV

Sequence Length  17

UniProt ID  No entry found

Source  Synthetic construct(derived from LL-37)



Activity Information


Target Organism  EBOV

Assay  Plaque assay

Activity 

  • [Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.71 µM);inhibition of viral infection in primary macrophages(IC50=5.6 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  The 'X' at position 2 and 12 indicates biphenylalanine.

Stereochemistry  Mixed(D-Leu5, 9, 13)



Physicochemical Information


Formula  C61H103N25O12

Absent amino acids  ACEFHIMPSTWY

Common amino acids  R

Mass  2030.86

Pl  11.72

Basic residues  5

Acidic residues  1

Hydrophobic residues  3

Net charge  4

Boman Index  -6282

Hydrophobicity  -117.65

Aliphatic Index  57.06

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.

Pubmed ID   32252021

Reference   iScience. 2020 Apr 24;23(4):100999.

Author   Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.

DOI   10.1016/j.isci.2020.100999