General Information
DRAVP ID DRAVPe01805
Peptide Name 17BIPHE2
Sequence GXKRlVQRlKDXlRNLV
Sequence Length 17
UniProt ID No entry found
Source Synthetic construct(derived from LL-37)
Activity Information
Target Organism EBOV
Assay Plaque assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification The 'X' at position 2 and 12 indicates biphenylalanine.
Stereochemistry Mixed(D-Leu5, 9, 13)
Physicochemical Information
Formula C61H103N25O12
Absent amino acids ACEFHIMPSTWY
Common amino acids R
Mass 2030.86
Pl 11.72
Basic residues 5
Acidic residues 1
Hydrophobic residues 3
Net charge 4
Boman Index -6282
Hydrophobicity -117.65
Aliphatic Index 57.06
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Literature Information
Literature 1
Title Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.
Pubmed ID 32252021
Reference iScience. 2020 Apr 24;23(4):100999.
Author Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.