To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01807
Peptide Name NC-783
Sequence KRRGGGKLLKLLLKLLLKLLKC
Sequence Length 22
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism RSV
Assay Antiviral assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism It is likely that these peptides exert anti-RSV activity through a combination of two mechanisms: destabilization of the viral envelope and competitive inhibition of attachment/fusion of the virus with the target cell.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C117H222N34O23S
Absent amino acids ADEFHIMNPQSTVWY
Common amino acids L
Mass 2505.32
Pl 11.27
Basic residues 8
Acidic residues 0
Hydrophobic residues 10
Net charge 8
Boman Index -984
Hydrophobicity 31.36
Aliphatic Index 177.27
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Linear and dendrimeric antiviral peptides: design, chemical synthesis and activity against human respiratory syncytial virus.
Pubmed ID 32124885
Reference J Mater Chem B. 2020 Apr 1;8(13):2607-2617
Author Kozhikhova KV, Shilovskiy IP, Shatilov AA, Timofeeva AV, Turetskiy EA, Vishniakova LI, Nikolskii AA, Barvinskaya ED, Karthikeyan S, Smirnov VV, Kudlay DA, Andreev SM, Khaitov MR
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.