To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01808
Peptide Name SA-35
Sequence MITHGCYTRTRHKHKLKKTL
Sequence Length 20
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism RSV
Assay Antiviral assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism It is likely that these peptides exert anti-RSV activity through a combination of two mechanisms: destabilization of the viral envelope and competitive inhibition of attachment/fusion of the virus with the target cell.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C107H182N36O26S2
Absent amino acids ADEFNPQSVW
Common amino acids KT
Mass 2452.97
Pl 10.58
Basic residues 9
Acidic residues 0
Hydrophobic residues 3
Net charge 9
Boman Index -5711
Hydrophobicity -111
Aliphatic Index 58.5
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 78.42
Polar residues 7
Literature Information
Literature 1
Title Linear and dendrimeric antiviral peptides: design, chemical synthesis and activity against human respiratory syncytial virus.
Pubmed ID 32124885
Reference J Mater Chem B. 2020 Apr 1;8(13):2607-2617
Author Kozhikhova KV, Shilovskiy IP, Shatilov AA, Timofeeva AV, Turetskiy EA, Vishniakova LI, Nikolskii AA, Barvinskaya ED, Karthikeyan S, Smirnov VV, Kudlay DA, Andreev SM, Khaitov MR
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.