To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01810
Peptide Name C20-Jp-Hp
Sequence ARLPRKKWK
Sequence Length 9
UniProt ID None
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV
Assay Cytopathic effect inhibition
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Hemagglutinin protein
Mechanism The ARLPR is a sialic acid mimic, the compound was demonstrated to bind the fusogenic region of HA, as indicated by CD spectra registered for the fusion peptide alone or in presence of C20-Jp-Hp
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification C20
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C55H95N19O10
Absent amino acids NDCQEGHIMFSTYVOU
Common amino acids K
Mass 1182.48
Pl 12.02
Basic residues 5
Acidic residues 0
Hydrophobic residues 3
Net charge 5
Boman Index 4.15
Hydrophobicity -1.956
Aliphatic Index 54.44
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 4.651
Polar residues 0
Literature Information
Literature 1
Title A "building block" approach to the new influenza A virus entry inhibitors with reduced cellular toxicities
Pubmed ID 26952867
Reference Scientific reports, 6, 22790.
Author Lin, D., Li, F., Wu, Q., Xie, X., Wu, W., Wu, J., Chen, Q., Liu, S., & He, J. (2016).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.