General Information

General Information

DRAVP ID DRAVPe01811

Peptide Name Hp1090

Sequence IFKAIWSGIKSLF

Sequence Length 13

UniProt ID P0DJ02,T1DEJ9

Source Heterometrus petersii

Activity Information

Target Organism HCV

Assay In vitro HCV RNA inhibitory assay

Activity

[Ref.20950663]Hepatitis C virus (HCV): inhibition of viral infection in Huh7.5.1 cells(IC50 = 7.62 μg/ml (5.0 μM)).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.20950663]the peptide concentration was less than 20 μg/ml, the viability of the peptide-treated cells was greater than 90%.

Binding Target membrane

Mechanism Has the ability to prevent the initiation step of HCV infection by direct interaction with HCV virus and readily disrupting their phospholipid membrane.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C76H116N16O16

Absent amino acids CDEHMNPQRTVY

Common amino acids I

Mass 1509.85

Pl 10

Basic residues 2

Acidic residues 0

Hydrophobic residues 8

Net charge 2

Boman Index 1282

Hydrophobicity 107.69

Aliphatic Index 127.69

Half Life

Mammalian:20 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 458.33

Polar residues 3

Literature Information

Literature 1

Title A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV.

Pubmed ID 20950663

Reference Peptides. 2011 Jan;32(1):11-9.

Author Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W.

DOI 10.1016/j.peptides.2010.10.008