DRAVP ID  DRAVPe01818

Peptide Name   Eval418-FH3

Sequence  LWHHIWNFVHGLI

Sequence Length  13

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV-1

Assay  Plaque reduction assay

Activity 

• [Ref.29290802]Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells(IC50=1.01 µg/mL); inhibition of viral attachment in Vero cells(IC50=0.86 µg/mL); inhibition of viral entry in Vero cells(IC50=4.23 µg/mL).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.29290802]Vero cells: CC50 = 26.83 µg/mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID   29290802

Reference   Theranostics. 2018 Jan 1;8(1):199-211.

Author   Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI   10.7150/thno.21425